Synthesis and antibacterial activity of 4″,11-di-O-arylalkylcarbamoyl azithromycin derivatives
作者： Shutao Ma , Bo Jiao , Zhaopeng Liu , Hui Wang , Ruiqing Xian
DOI: 10.1016/J.BMCL.2009.01.092
关键词: Microbiology 、 Antibacterial activity 、 Chemistry 、 Bacteria 、 Antibacterial agent 、 Chemical synthesis 、 Streptococcaceae 、 Biological activity 、 Streptococcus pneumoniae 、 Stereochemistry 、 Azithromycin 、 Organic chemistry 、 Clinical biochemistry 、 Molecular medicine 、 Biochemistry 、 Molecular biology 、 Drug discovery 、 Pharmaceutical Science
摘要: Abstract A series of new 4″,11-di-O-arylalkylcarbamoyl azithromycin derivatives were designed, synthesized and evaluated for their in vitro antibacterial activities. Some exhibited greatly improved activity against erythromycin-resistant bacteria. Among them, compounds 5f 5k found to have potent Streptococcus pneumoniae whose resistance was encoded by the erm or mef gene.
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