Novel C-4'' modified azithromycin analogs with remarkably enhanced activity against erythromycin-resistant Streptococcus pneumoniae: the synthesis and antimicrobial evaluation.
作者： Xiaodong Ma , Ling Zhang , Rongmei Wang , Jichao Cao , Chen Liu
DOI: 10.1016/J.EJMECH.2011.08.001
关键词:
摘要: Abstract Three novel structural series of C-4″ modified azithromycin analogs with two amide groups, which were connected by different alkyl linkage, designed, prepared and evaluated for their in vitro antibacterial activity against seven phenotypes respiratory pathogens. Among them, 7d, 8j 9j, as representatives corresponding series, exhibited remarkably improved erythromycin-resistant Streptococcus pneumoniae expressing the erm gene, mef genes. In addition, 7a–c, 7f–h, 7j, 8d, 8g, 8i, 9a–b 9i displayed favorable efficacy S. A22072 gene.
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