Effects of indomethacin on hormonal and blood pressure responses to captopril in spontaneously hypertensive rats.
作者： Pekka Säynävälammi , Pertti Arvola , Kari Kuismanen , Erkki Seppälä , Anna-Kaisa Nurmi
DOI: 10.1111/J.1600-0773.1987.TB01802.X
关键词:
摘要: The possible role of vasodilatory prostanoids in the antihypertensive action captopril was investigated spontaneously hypertensive rats (SHR). Captopril (100 mg/kg/day for 5 days) decreased systolic blood pressure and increased water consumption, urine excretion plasma renin activity (PRA). It also enhanced urinary prostacyclin metabolite 6-keto-PGF1 alpha, but did not change PGE2. Indomethacin (3 mg/kg/day), given both alone combination with captopril, reduced markedly excretions alpha PGE2 alter PRA, compared corresponding groups without indomethacin. suppression prostanoid synthesis caused by indomethacin affect effect or basal SHR. Neither influence drinking SHR receiving it dipsogenic diuretic effects captopril. results suggest that augments production prostacyclin. Yet have no significant mechanism
sci-hub.se 参考文章(18)
E. L. Schiffrin, J. Genest, Mechanism of captopril-induced drinking American Journal of Physiology-regulatory Integrative and Comparative Physiology. ,vol. 242, ,(1982) , 10.1152/AJPREGU.1982.242.1.R136
Ronald A. Ferrone, Michael J. Antonaccio, Prevention of the development of spontaneous hypertension in rats by captopril (SQ 14,225) European Journal of Pharmacology. ,vol. 60, pp. 131- 137 ,(1979) , 10.1016/0014-2999(79)90211-5
María de Fátima Pérez Guaita, Emma Chiaraviglio, Effect of prostaglandin E1 and its biosynthesis inhibitor indomethacin on drinking in the rat Pharmacology, Biochemistry and Behavior. ,vol. 13, pp. 787- 792 ,(1980) , 10.1016/0091-3057(80)90208-7
Pekka Säynäväulammi, Effects of Captopril on the Urinary Excretion of Prostanoids and Kallikrein in Spontaneously Hypertensive Rats Acta Pharmacologica et Toxicologica. ,vol. 59, pp. 285- 290 ,(2009) , 10.1111/J.1600-0773.1986.TB00170.X
T. Fujita, N. Yamashita, K. Yamashita, Effect of indomethacin on antihypertensive action of captopril in hypertensive patients. Clinical and Experimental Hypertension. ,vol. 3, pp. 939- 952 ,(1981) , 10.3109/10641968109033714
Stephen L. Swartz, Gordon H. Williams, Angiotensin-Converting Enzyme Inhibition and Prostaglandins American Journal of Cardiology. ,vol. 49, pp. 1405- 1409 ,(1982) , 10.1016/0002-9149(82)90351-4
P.H. Vlasses, R.K. Ferguson, J.B. Smith, H.H. Rotmensch, B.N. Swanson, Urinary excretion of prostacyclin and thromboxane A2 metabolites after angiotensin converting enzyme inhibition in hypertensive patients Prostaglandins, Leukotrienes and Medicine. ,vol. 11, pp. 143- 150 ,(1983) , 10.1016/0262-1746(83)90014-8
Michael J. Dunn, Edward J. Zambraski, Renal effects of drugs that inhibit prostaglandin synthesis Kidney International. ,vol. 18, pp. 609- 622 ,(1980) , 10.1038/KI.1980.179
HIROSHI MIKAMI, TOSHIO OGIHARA, HIRONORI OHDE, TORU NAKA, YUICHI KUMAHARA, Evaluation of hypotensive mechanisms of captopril in addition to its inhibition of the converting enzyme in spontaneously hypertensive rats. Japanese Circulation Journal-english Edition. ,vol. 46, pp. 1154- 1158 ,(1982) , 10.1253/JCJ.46.1154
Erkki Seppälä, Olavi Pora, Timo Metsä-Ketelä, A modified method for extraction and purification of prostaglandins with resin XAD-2. Prostaglandins, Leukotrienes and Medicine. ,vol. 14, pp. 235- 241 ,(1984) , 10.1016/0262-1746(84)90207-5