Effect of indomethacin on antihypertensive action of captopril in hypertensive patients.

摘要: To evaluate the role of prostaglandin systems in mediating response blood pressure (BP) to converting enzyme inhibitor, single dose captopril, 100 mg, was administered orally thirteen patients with essential hypertension, during three experimental periods: on a normal-sodium diet (150 mEq per day), low-sodium (30 and following indomethacin 150 mg daily for days. During periods, BP significantly decreased after administration accompanied by significant increase urinary PGE2 excretion. With treatment, captopril-induced fall markedly inhibited, not associated apparent The evidence presented suggests that antihypertensive effect captopril may be due overproduction prostaglandin, addition reduction circulating angiotensin II. Moreover, indomethacin-inhibiting caused more exhibited renin-nonresponder subjects than renin-responder subjects. These results suggest play an important vasodepressor action especially low-renin group.