Systemic Electroporation – Combining Electric Pulses with Bioactive Agents

摘要: In the year 2007, documentation of first functionally effective electrotransfer naked DNA by electroporation, with stable gene expression, is 25 years old. This functional electro-uptake has been preceded, in 1972, controlled electrorelease cellular components from bovine medullar chromaffin granules. - meantime, electroporation field pulse techniques combined application bioactive agents, have culminated new clinical disciplines electrochemotherapy and electrogenetherapy. There are continuously ongoing efforts to improve protocols optimizing equipment cell biological strategies, relying heavily on increasing knowledge molecular-mechanistic details derived various data. The digression here restricted a survey-like appreciation early data their thermodynamic mechanistic interpretation. We briefly touch potential explore systemic for treatments tissue, particular, tumors. goal provide tools order optimize design electrode arrays use.