APOBEC3B and IL-6 form a positive feedback loop in hepatocellular carcinoma cells.
作者： Shuran Li , Xueyang Bao , Duowei Wang , Linjun You , Xianjing Li
DOI: 10.1007/S11427-016-9058-6
关键词:
摘要: APOBEC3 protein families, a DNA cytidine deaminase, were up-regulated in multiple tumors. However, the relationship between Hepatocellular carcinoma (HCC) and APOBEC3B (A3B) remains unknown. It has been confirmed that interleukin-6 (IL-6) significant impacts on oncogenesis of HCC. Here, we reported expression IL-6 was substantially by A3B HepG2 cells. induced through relocating HuR to enhance mRNA stability. Further analysis indicated also increased JAK1/STAT3 signaling pathway, which formed positive feedback maintain continuous IL-6, thereby promoted prolonged non-resolving inflammation. Collectively, these findings suggest is essential for HCC, potential target preventive intervention.
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