Anti-viral protein APOBEC3G is induced by interferon-α stimulation in human hepatocytes

摘要: Apolipoprotein B mRNA-editing enzyme catalytic-polypeptide 3G (APOBEC3G) is a potent inhibitor of infection by wide range retroviruses. Although recent reports have suggested that human APOBEC3G exerts antiviral activity against hepatitis virus, expression normally low in the liver. To clarify role cellular defenses viruses, regulation was investigated hepatocytes. Endogenous transcripts nine APOBEC family members were barely detectable quiescent liver cells. However, significantly up-regulated response to interferon-alpha (IFN-alpha) stimulation HepG2, Huh-7, and primary IFN regulatory factor elements are important for IFN-inducible promoter identified 5' upstream from gene. Our findings provided first evidence showing induced hepatocytes thus could be involved host defense mechanisms directed viruses.