Interferon‐inducible GTPases in cell autonomous and innate immunity

Jörn Coers, Isaac Bernstein-Hanley, David Grotsky, Iana Parvanova, Jonathan C. Howard, Gregory A. Taylor, William F. Dietrich, Michael N. Starnbach, Chlamydia muridarum Evades Growth Restriction by the IFN-γ-Inducible Host Resistance Factor Irgb10 Journal of Immunology. ,vol. 180, pp. 6237- 6245 ,(2008) , 10.4049/JIMMUNOL.180.9.6237

Jun Ohshima, Miwa Sasai, Jianfa Liu, Kazuo Yamashita, Ji Su Ma, Youngae Lee, Hironori Bando, Jonathan C. Howard, Shigeyuki Ebisu, Mikako Hayashi, Kiyoshi Takeda, Daron M. Standley, Eva-Maria Frickel, Masahiro Yamamoto, RabGDIα is a negative regulator of interferon-γ–inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii Proceedings of the National Academy of Sciences. ,vol. 112, pp. E4581- E4590 ,(2015) , 10.1073/PNAS.1510031112

C T Capaldo, N Beeman, R S Hilgarth, P Nava, N A Louis, E Naschberger, M Stürzl, C A Parkos, A Nusrat, IFN-γ and TNF-α-induced GBP-1 inhibits epithelial cell proliferation through suppression of β-catenin/TCF signaling Mucosal Immunology. ,vol. 5, pp. 681- 690 ,(2012) , 10.1038/MI.2012.41

Aliaksandr Khaminets, Julia P. Hunn, Stephanie Könen-Waisman, Yang O. Zhao, Daniela Preukschat, Jörn Coers, Jon P. Boyle, Yi-Ching Ong, John C. Boothroyd, Gabriela Reichmann, Jonathan C. Howard, Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole. Cellular Microbiology. ,vol. 12, pp. 939- 961 ,(2010) , 10.1111/J.1462-5822.2010.01443.X

Elizabeth Di Russo Case, Audrey Chong, Tara D. Wehrly, Bryan Hansen, Robert Child, Seungmin Hwang, Herbert W. Virgin, Jean Celli, The Francisella O-antigen mediates survival in the macrophage cytosol via autophagy avoidance. Cellular Microbiology. ,vol. 16, pp. 862- 877 ,(2014) , 10.1111/CMI.12246

Youssef Aachoui, Yuji Kajiwara, Irina A. Leaf, Dat Mao, Jenny P.-Y. Ting, Jörn Coers, Alan Aderem, Joseph D. Buxbaum, Edward A. Miao, Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium Cell Host & Microbe. ,vol. 18, pp. 320- 332 ,(2015) , 10.1016/J.CHOM.2015.07.016

Thorsten Klamp, Ulrich Boehm, Daniela Schenk, Klaus Pfeffer, Jonathan C. Howard, A giant GTPase, very large inducible GTPase-1, is inducible by IFNs. Journal of Immunology. ,vol. 171, pp. 1255- 1265 ,(2003) , 10.4049/JIMMUNOL.171.3.1255

Jianjin Shi, Yue Zhao, Kun Wang, Xuyan Shi, Yue Wang, Huanwei Huang, Yinghua Zhuang, Tao Cai, Fengchao Wang, Feng Shao, Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death Nature. ,vol. 526, pp. 660- 665 ,(2015) , 10.1038/NATURE15514

Nobuhiko Kayagaki, Irma B. Stowe, Bettina L. Lee, Karen O’Rourke, Keith Anderson, Søren Warming, Trinna Cuellar, Benjamin Haley, Merone Roose-Girma, Qui T. Phung, Peter S. Liu, Jennie R. Lill, Hong Li, Jiansheng Wu, Sarah Kummerfeld, Juan Zhang, Wyne P. Lee, Scott J. Snipas, Guy S. Salvesen, Lucy X. Morris, Linda Fitzgerald, Yafei Zhang, Edward M. Bertram, Christopher C. Goodnow, Vishva M. Dixit, Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling Nature. ,vol. 526, pp. 666- 671 ,(2015) , 10.1038/NATURE15541

Petr Broz, Denise M. Monack, Molecular mechanisms of inflammasome activation during microbial infections Immunological Reviews. ,vol. 243, pp. 174- 190 ,(2011) , 10.1111/J.1600-065X.2011.01041.X