Quo vadis? Interferon-inducible GTPases go to their target membranes via the LC3-conjugation system of autophagy

摘要: Many intracellular pathogens survive and replicate within vacuole-like structures in the cytoplasm. It has been unclear how host immune system controls such pathogen-containing vacuoles. Interferon-inducible GTPases are dynamin-like that target membranes of Upon their oligomerization on membrane, vacuole structure disintegrates pathogen gets exposed to hostile What obscure is detects directs these shelters. Using a common protist parasite mice, Toxoplasma gondii, we found LC3 conjugation autophagy necessary sufficient for targeting interferon-inducible membranes. We dubbed this process Targeting by AutophaGy proteins (TAG). In canonical autophagy, required form membrane-bound autophagosomes, which encircle deliver cytosolic materials lysosomes degradation. TAG, however, mark vacuoles with ubiquitin-like homologs, function as molecular beacons recruit Our data suggest plays an essential role detecting marking effector system.