Pharmaceutical formulations for the treatment and prevention of trauma-induced neuropathology and neurodegeneration

摘要: Novel multi-component formulations, procedures and methods for use in treating neuropathology neurodegeneration incident to trauma are provided. Multi-component formulations of the invention comprise biologically active forms any two, three, or all four at least one neurosteroid neuroactive steroid, such as progesterone synthetic progestin, anti-epileptic anticonvulsant, gabapentin, pregabalin valproic acid, NK-1 receptor antagonist, aprepitant, casopitant vestipitant, lithium-containing lithium-related drug. The provided configured adapted prevent reduce incidence severity neurological damage caused by trauma, risk damage. Formulations, advantageously effect both neuroprotective actions secondary injuries, neurotrophic repair restore cells tissues affected especially useful injury nerve cells, neural support tissues.