Association of single nucleotide polymorphisms in endothelin family genes with the progression of atherosclerosis in patients with essential hypertension

摘要: Endothelin-1 (ET-1) is a potent vasoconstrictive peptide and its activity mediated by the receptors ET type A (EDNRA) B (EDNRB). Although ET-1 thought to play an important role in development of atherosclerosis, it remains unclear whether polymorphisms family genes, including gene (EDN1), EDNRA, EDNRB genes for endothelin converting enzymes 1 2 (ECE1 ECE2), are associated with progression atherosclerosis. We investigated relationship between 11 single nucleotide (SNPs) (including three EDN1, one two EDNRB, four ECE1 ECE2) atherosclerotic changes assessed using pulse wave velocity (PWV) carotid ultrasonography 630 patients essential hypertension (EHT). In male subjects, we found significant differences brachial-ankle PWV (baPWV) additive recessive models EDNRB-rs5351 after Bonferroni correction. Also there were mean intima-media thickness (IMT) EDNRA-rs5333 no correlation any SNPs baPWV, IMT Plaque score (PS) female subjects. Furthermore, multiple logistic regression analysis, only indicated as independent risk atherosclerosis hypertensive Of endothelin-related was most susceptible SNP hypertensives, genetic background may be involved EHT patients.