Vascularisation of tissue-engineered constructs

摘要: Abstract: A variety of biomaterials have been fabricated to replace tissues, either as an off-the-shelf option or a cell-seeded construct. The formation mature vascular supply throughout such materials is vital the success its integration into host tissue, long-term survival and regeneration mature, functional tissue. In this chapter, development healthy vasculature reviewed in context tissue engineering. importance blood for bone growth repair discussed, well various pathologies associated with uncontrolled dysfunctional supply, including tumorigenesis. number factors essential angiogenesis tested may be used alone, combination single cell type multicellular co-cultures. Stem cell, osteoblast endothelial co-culture techniques were optimised engineering vascularised scaffolds, vessel observed.