Polyamines in Cardiac Physiology and Disease~!2009-10-19~!2009-11-30~!2010-06-14~!
作者： Emanuele Giordano , Flavio Flamigni , Carlo Guarnieri , Claudio Muscari , Carla Pignatti
DOI: 10.2174/1876535101003020025
关键词:
摘要: The natural diamine putrescine and polyamines spermidine spermine belong to a family of low-molecular- weight organic polycations that are classically known be important mediators cell growth, proliferation division. Several studies nowadays available about the involvement in various aspects - such as differen- tiation death cardiac cells, under physiological pathological conditions. Polyamine metabolism effects, their relation with number extracellular signals intracellular transductional cascades, have been investigated cellular animal models comprising cultures embryo, neonatal adult primary cardiomyocytes, heart-derived lines, stem well wild-type transgenic animals. Significant evidence for critical role (mal)adaptive (patho)physiology emerges from this extensive literature suggesting that, principle, polyamine may constitute target treatment cardiovascular diseases. In present paper we reviewed these studies.
bentham-open.org
benthamopen.com参考文章(82)
R Poulin, G Pelletier, A E Pegg, Induction of apoptosis by excessive polyamine accumulation in ornithine decarboxylase-overproducing L1210 cells. Biochemical Journal. ,vol. 311, pp. 723- 727 ,(1995) , 10.1042/BJ3110723
Denise Hilfiker-Kleiner, Ulf Landmesser, Helmut Drexler, Molecular Mechanisms in Heart Failure: Focus on Cardiac Hypertrophy, Inflammation, Angiogenesis, and Apoptosis Journal of the American College of Cardiology. ,vol. 48, ,(2006) , 10.1016/J.JACC.2006.07.007
Jian-Ying Wang, Robert Anthony Casero, None, Polyamine cell signaling : physiology, pharmacology, and cancer research Humana Press. ,(2006)
Benedetta Tantini, Carla Pignatti, Monia Fattori, Flavio Flamigni, Claudio Stefanelli, Emanuele Giordano, Marta Menegazzi, Carlo Clô, Claudio Marcello Caldarera, NF‐κB and ERK cooperate to stimulate DNA synthesis by inducing ornithine decarboxylase and nitric oxide synthase in cardiomyocytes treated with TNF and LPS FEBS Letters. ,vol. 512, pp. 75- 79 ,(2002) , 10.1016/S0014-5793(02)02222-6
C Caldarera, Polyamines and noradrenaline following myocardial hypertrophy. Journal of Molecular and Cellular Cardiology. ,vol. 3, pp. 121- 126 ,(1971) , 10.1016/0022-2828(71)90038-1
Genzou Takemura, Hisayoshi Fujiwara, Morphological aspects of apoptosis in heart diseases. Journal of Cellular and Molecular Medicine. ,vol. 10, pp. 56- 75 ,(2006) , 10.1111/J.1582-4934.2006.TB00291.X
F FLAMIGNI, C ROSSONI, C STEFANELLI, C CALDARERA, Polyamine metabolism and function in the heart Journal of Molecular and Cellular Cardiology. ,vol. 18, pp. 3- 11 ,(1986) , 10.1016/S0022-2828(86)80977-4
K. GIBSON, P. HARRIS, The in-vitro and in-vivo effects of polyamines on cardiac protein biosynthesis Cardiovascular Research. ,vol. 8, pp. 668- 673 ,(1974) , 10.1093/CVR/8.5.668
Heather M. WALLACE, Alison V. FRASER, Alun HUGHES, A perspective of polyamine metabolism Biochemical Journal. ,vol. 376, pp. 1- 14 ,(2003) , 10.1042/BJ20031327
Nikolaus Seiler, Francis Raul, Polyamines and apoptosis. Journal of Cellular and Molecular Medicine. ,vol. 9, pp. 623- 642 ,(2005) , 10.1111/J.1582-4934.2005.TB00493.X