Use of pneumococcal vaccine in adults.

摘要: of the Clinical Problem Streptococcus pneumoniae is a commoncauseof upper respiratory tract infection and community-acquired pneumonia (CAP). It also causes invasivepneumococcaldisease(IPD)suchasbacteremia,bacterialmeningitis, endocarditis, andosteomyelitis. In2012, therewere anestimated31 600casesofpneumococcal infectionand3300related deaths in theUnited States. The highest rates are among children adults aged 65 years or older.1 PPSV23was licensed theUnitedStates 1983.According to 2013meta-analysis, this vaccine associated with prevention IPD, but there no consistent evidence that it associatedwith reduced all-cause all-causemortality.2 addition 7-valent PCV (PCV7) 2000 pediatric schedule was decreases both adult IPD.3PCV13 isanotherconjugated contains capsular polysaccharide antigens from 13 strains S (includingthe6Astrain,astrainnot included inPPSV23)conjugated inactivated diphtheria-tetanus toxoid. conjugated formulation thought elicit more robust T cell– dependent immune response than PPSV23, which processed through cell–independent pathway.4