作者: Tiffany Caza , Steve Landas
DOI: 10.1155/2015/521957
关键词:
摘要: The remarkable plasticity of CD4(+) T cells allows individuals to respond environmental stimuli in a context-dependent manner. A balance cell subsets is critical mount responses against pathogen challenges prevent inappropriate activation, maintain tolerance, and participate antitumor immune responses. Specification process beginning intrathymic development continuing within the circulation. It highly flexible adapt differences nutrient availability tissue microenvironment. have significant cross talk, with ability "dedifferentiate" given appropriate signals. This dependent on metabolic status cell, mTOR acting as rheostat. Autoimmune are regulated by between regulatory Th17 cells. When homeostatic not maintained, immunopathology can result. carry complex roles tumor microenvironments, influenced oncogenic drivers presence inflammation. Here, we examine signals involved specification towards each subset, interconnectedness cytokine networks, impact signaling, cellular metabolism lineage provide supplement describing techniques study these processes.