Sniffing shapes the dynamics of olfactory bulb gamma oscillations in awake behaving rats

摘要: Mammals actively sample the environment for relevant olfactory objects. This active sampling is revealed by rapid changes in respiratory rate that influence input. Yet role of sniffing shaping neural responses to odorants has not been elucidated. In bulb (OB), odorant-evoked gamma oscillations reflect synchronous activity mitral/tufted cells, a proposed mechanism odorant representation. Here we examined effect frequency on OB. We simultaneously recorded and local field potential while rats performed lick/no-lick discrimination task with low concentrations. High-frequency (HFS) augmented power oscillations, suggesting an increase sensitivity odorants. By contrast, coupling sniff cycle amplitude individual bursts were modified rate. However, HFS prolonged overall response increased indicating reduces adaptation continuous stimulation. Therefore, during result more frequent extended As can be single sniff, reduction mediated novel may facilitate memory formation subsequent identification. Finally, these results corroborate should integrated study coding behaving animals.