Ferromagnetic microdisks as carriers for biomedical applications

摘要: We report the fabrication process, magnetic behavior, as well surface modification of ferromagnetic microdisks suspended in aqueous solution. They posses unique properties such high magnetization saturation, zero remanence due to spin vortex formation, intrinsic resonance at low frequencies, and capability delivering various biomolecules once. Furthermore, because their anisotropic shape, our particles rotate under alternating fields small amplitude. This can be used promote idea advanced therapies, which include combined drug delivery magnetomechanical cell destruction when targeting tumor cells. The approach enables us fabricate suitable carriers with excellent size tolerances, then release them from wafer into solution, ready for therapeutic use. have a core are covered few nanometers gold on each side provide stability ambient conditions biocompatibility selective adhesion functions. A successful attempt bind thiolates, including SH-modified antibody, disk’s was demonstrated.