Diagnostic and prognostic role of biomarkers for pulmonary hypertension in interstitial lung disease
作者： Charlotte U. Andersen , Søren Mellemkjær , Jens Erik Nielsen-Kudsk , Elisabeth Bendstrup , Ulf Simonsen
DOI: 10.1016/J.RMED.2012.09.003
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摘要: Summary Background Pulmonary hypertension (PH) is an important complication to interstitial lung disease (ILD). The aim of the present study was investigate relation NT-proBNP, fibrin D-dimer, troponin-T, uric acid and exhaled nitric oxide (NO) presence PH mortality in ILD. Methods In a previously described cohort 212 ILD patients whom 29 had PH, levels above mentioned biomarkers were analyzed as routine tests. Results A value NT-proBNP below 95 ng/l negative predictive for 99% (95% CI: 94–100). Values troponin-T higher with (median (inter quartile range) = 9 (9–20) vs. 9(9–10) ng/l), odds ratio (OR) increased abnormal (OR CI) = 3.1(1.1–8.8)). values 50 th percentile, D-dimer 90th percentile each associated mortality. Conclusions may be used rule-out test ILD, while risk factor PH. have prognostic patients, NO do not seem predict or
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