Antiproliferative and antioxidant properties of Alhagi maurorum Boiss (Leguminosae) aerial parts
作者： Monica R Loizzo , Khaled Rashed , Ataa Said , Marco Bonesi , Francesco Menichini
DOI: 10.1016/J.INDCROP.2013.12.049
关键词:
摘要: Abstract This work is aimed to investigate the antiproliferative and antioxidant activities of Alhagi maurorum, a legume used as natural sweetener. Diethyl ether (DE) petroleum (PE) extracts were analyzed for their chemical composition by GC–MS analysis. Both extract further investigated potential cytotoxicity against panel human cancer cell lines sulforhodamine B (SRB) assay. DE extract, characterized fatty acids coumarins main constituents, showed strongest activity C32 melanoma line with an IC50 value 2.7 μg/ml. For investigation different in vitro systems, namely 2,2-diphenylpicrylhydrazyl (DPPH), 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS*+), μ-carotene bleaching test, ferric reducing ability power assay (FRAP) Fe-chelating employed. highest radical scavenging ABTS 4.7 μg/ml. was also able reduce metal transition ion iron FRAP 69.6 μM Fe(II)/g that comparable positive control butylated hydroxytoluene (BHT) (63.2 μM Fe(II)/g). These biological properties may be interest from functional point view propose alternative use this edible legume.
sci-hub.se 参考文章(38)
Armin Oskoueian, Reza Sadrabadi Haghighi, Mahmood Ebrahimi, Antioxidant activity, total phenolic and flavonoid compounds in Prunus mahaleb L. seed Clinical Biochemistry. ,vol. 44, ,(2011) , 10.1016/J.CLINBIOCHEM.2011.08.855
A.H. Atta, K. Abo EL-Sooud, The antinociceptive effect of some Egyptian medicinal plant extracts Journal of Ethnopharmacology. ,vol. 95, pp. 235- 238 ,(2004) , 10.1016/J.JEP.2004.07.006
Rosa Tundis, Brigitte Deguin, Monica R. Loizzo, Marco Bonesi, Giancarlo A. Statti, François Tillequin, Francesco Menichini, Potential antitumor agents: Flavones and their derivatives from Linaria reflexa Desf. Bioorganic & Medicinal Chemistry Letters. ,vol. 15, pp. 4757- 4760 ,(2005) , 10.1016/J.BMCL.2005.07.029
Saeed Ahmad, Naheed Riaz, Muhammad Saleem, Abdul Jabbar, Nisar-Ur-Rehman, Mohammad Ashraf, Antioxidant flavonoids from Alhagi maurorum Journal of Asian Natural Products Research. ,vol. 12, pp. 138- 143 ,(2010) , 10.1080/10286020903451724
MARSDEN S. BLOIS, Antioxidant Determinations by the Use of a Stable Free Radical Nature. ,vol. 181, pp. 1199- 1200 ,(1958) , 10.1038/1811199A0
Monica R. Loizzo, Rosa Tundis, Marco Bonesi, Federica Menichini, Vincenzo Mastellone, Luigi Avallone, Francesco Menichini, Radical scavenging, antioxidant and metal chelating activities of Annona cherimola Mill. (cherimoya) peel and pulp in relation to their total phenolic and total flavonoid contents Journal of Food Composition and Analysis. ,vol. 25, pp. 179- 184 ,(2012) , 10.1016/J.JFCA.2011.09.002
Joon-Kwan Moon, Takayuki Shibamoto, Antioxidant assays for plant and food components. Journal of Agricultural and Food Chemistry. ,vol. 57, pp. 1655- 1666 ,(2009) , 10.1021/JF803537K
Lisha You, Rui An, Xinhong Wang, Yimin Li, Discovery of novel osthole derivatives as potential anti-breast cancer treatment. Bioorganic & Medicinal Chemistry Letters. ,vol. 20, pp. 7426- 7428 ,(2010) , 10.1016/J.BMCL.2010.10.027
Toshihiro FUJIOKA, Kazuhiro FURUMI, Hiroko FUJII, Hikaru OKABE, Kunihide MIHASHI, Yukitaka NAKANO, Hisashi MATSUNAGA, Mitsuo KATANO, Masato MORI, Antiproliferative constituents from umbelliferae plants. V. A new furanocoumarin and falcarindiol furanocoumarin ethers from the root of Angelica japonica Chemical & Pharmaceutical Bulletin. ,vol. 47, pp. 96- 100 ,(1999) , 10.1248/CPB.47.96
Mihalis Panayiotidis, Reactive oxygen species (ROS) in multistage carcinogenesis Cancer Letters. ,vol. 266, pp. 3- 5 ,(2008) , 10.1016/J.CANLET.2008.02.027