A neglected GABAergic astrocyte: Calcium dynamics and involvement in seizure activity

摘要: Gamma-aminobutyric acid (GABA) contributes substantially to neurocognitive function as an important inhibitory neurotransmitter in the human cerebral cortex. However, pathophysiology of disorders such epilepsy are not well understood, since GABA agonists quite effective treating epilepsy. Knowledge mechanism action would contribute review previously proposed anti-epileptic processes by agonists. In this study based on recent experiments GABAergic astrocytes, we developed a modified astrocyte model, and successfully simulated long-lasting Ca2+ oscillation astrocytes after 0.5-s stimulation transmission. We then incorporated model into classical Ullah-Schiff seizure surprisingly found that functions hinder agonists, thereby explaining their low efficiency previous experiments. These results also update our knowledge effects physiological pathological brain.