Reactivation of Hepatitis B

摘要: Reactivation of hepatitis B refers to the abrupt increase in virus (HBV) replication a patient with inactive or resolved B. can occur spontaneously, but more typically is triggered by immunosuppressive therapy cancer, autoimmune disease, organ transplantation. be transient and clinically silent, often causes flare disease that severe resulting acute hepatic failure. Most instances reactivation resolve if immune suppression continued, re-establishment chronic occurs which lead progressive liver injury cirrhosis. The best-described surface antigen (HBsAg) carriers minimally active who are given cancer chemotherapy for lymphoma leukemia. Typically, serum HBV DNA rises during chemotherapy, followed clearance reconstitution after stopped. Special forms solid bone marrow transplantation infection results. Several randomized, placebo-controlled trials have shown prevented antiviral prophylaxis. Routine prophylaxis therefore recommended persons HBsAg undergoing transplantation, major questions remain. Which patients should screened all treated? used how long? Should without receive prophylaxis? Future research address underlying molecular mechanisms as well its optimal means diagnosis, treatment, prevention different populations.