Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73)

摘要: Objective  To examine the traditional diet-heart hypothesis through recovery and analysis of previously unpublished data from Minnesota Coronary Experiment (MCE) to put findings in context existing randomized controlled trials a systematic review meta-analysis. Design  The MCE (1968-73) is double blind trial designed test whether replacement saturated fat with vegetable oil rich linoleic acid reduces coronary heart disease death by lowering serum cholesterol. Recovered documents raw were analyzed according hypotheses prespecified original investigators. Further, meta-analyses that lowered cholesterol providing place without confounding concomitant interventions was conducted. Setting  One nursing home six state mental hospitals Minnesota, United States. Participants  Unpublished completed analyses for cohort 9423 women men aged 20-97; longitudinal on 2355 participants exposed study diets year or more; 149 autopsy files. Interventions  Serum diet replaced (from corn polyunsaturated margarine). Control high animal fats, common margarines, shortenings. Main outcome measures  Death all causes; association between changes death; atherosclerosis myocardial infarcts detected at autopsy. Results intervention group had significant reduction compared controls (mean change baseline −13.8% v −1.0%; P Conclusions  Available evidence shows effectively lowers but does not support this translates lower risk causes. Findings add growing incomplete publication has contributed overestimation benefits replacing oils acid.