Diet-Induced Changes in n-3- and n-6-Derived Endocannabinoids and Reductions in Headache Pain and Psychological Distress

摘要: Abstract Omega-3 and omega-6 fatty acids are biosynthetic precursors of endocannabinoids with antinociceptive, anxiolytic, neurogenic properties. We recently reported that targeted dietary manipulation—increasing omega-3 while reducing linoleic acid (the H3-L6 intervention)—reduced headache pain psychological distress among chronic patients. It is not yet known whether these clinical improvements were due to changes in related mediators derived from acids. therefore used data this trial (N = 55) investigate 1) the intervention altered omega-3- omega-6-derived plasma 2) diet-induced bioactive lipids associated improvements. The significantly increased docosahexaenoic derivatives 2-docosahexaenoylglycerol (+65%, P  = .001). Diet-induced endocannabinoid acid, but arachidonic correlated reductions physical distress. These findings demonstrate manipulation can alter humans suggest docosahexaenoylethanolamine could have and/or modulating Trial registration: ClinicalTrials.gov (NCT01157208) Perspective This article demonstrates interventions provide an effective, complementary approach for managing conditions.