The development and use of T cell receptor peptide vaccines.

摘要: Autoreactivity is a normal feature of the immune system which must be able to distinguish self from non-self. However, when this autoreactivity results in pathological tissue damage, autoimmune diseases result. While can associated with autoreactive T cells or autoantibodies, many major are considered cell mediated. These include rheumatoid arthritis, multiple sclerosis, psoriasis and type I diabetes. In developing strategies treat mediated disease conditions, one consider as pathogens. Thus, approach therapies for by using similar those used control other pathogens, such virus bacteria. involving immunization attenuated subunit forms these