1,2,4-Triazolo-quinazoline-thiones: Non-conventional synthetic approach, study of solvatochromism and antioxidant assessment.
作者： Rajesh Sompalle , Selvaraj Mohana Roopan , Naif Abdullah Al-Dhabi , K. Suthindhiran , Gargi Sarkar
DOI: 10.1016/J.JPHOTOBIOL.2016.06.051
关键词:
摘要: A non-conventional methodology has been utilized for the synthesis of a series 1,2,4-triazolo-quinazoline-thiones (2a-l). Here reaction was carried out between 1,2,4-triazolo-quinazolinones (1a-l), in presence 1,4-dioxane. The mixture irradiated under microwave (100W) 7min to obtain targeted molecules All synthesized were confirmed by (1)H, (13)C NMR and HRMS. solvatochromic property (absorption spectra) compounds (2a-l) solvents different polarities studied. further subjected their vitro free radical screening using 2,2-diphenyl-1-picrylhydrazyl (DPPH) method also screened anti-fungal against Aspergillus flavus (A. flavus) niger niger). results from scavenging assay showed promising activity 2a, e-i, whereas compound 2d significant antioxidant when compared ascorbic acid. In study that had A. with widely used antifungal agent Fluconazole.
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