Kinetics of multistep hole transfer in DNA by monitoring the transient absorption of the pyrene radical cation
作者： Tadao Takada , Kiyohiko Kawai , Sachiko Tojo , Tetsuro Majima
DOI: 10.1021/JP035750K
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摘要: To clarify the hole-transfer mechanism in DNA and factor controlling rates, kinetics of hole transfer was studied by monitoring transient absorption pyrene (Py) radical cation (Py•+) during pulse radiolysis oligodeoxynucleotides (ODNs) conjugated with Py. By analyzing Py•+ formed from to Py, rate constants various sequences were determined. The nearest guanine (G) Py weakly dependent upon distance between G, indicating occurrence multistep DNA. In contrast, where rate-determining step single-step Gs, strongly Gs. Comparing intervening nucleobases increased order G•+AG > G•+AC G•+TG. Thes...
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