FOXO1 is a tumor suppressor in cervical cancer.
作者： B. Zhang , L.S. Gui , X.L. Zhao , L.L. Zhu , Q.W. Li
关键词:
摘要: Forkhead box protein O1 (FOXO1) is an important transcriptional regulator of cell proliferation, and considered essential for tumor growth progression. However, the function FOXO1 in human cervical cancer remains unclear. In this study, we investigated role cancer. Our results showed that expression was lower than intraepithelial neoplasia normal cervix by immunohistochemical analysis (P < 0.05). The level high-grade lesions significantly low-grade lesion 0.05), indicating deficient involved progression associated with late-stage tumors which further supported clinicopathological, real-time polymerase chain reaction, Western blotting analysis. Moreover, confirmed overexpression remarkably repressed blocked accompanied cell-cycle arrest G2/M phase upregulation caspases-3 -9 gene expression. Collectively, our data suggest plays a vital inhibiting development inducing apoptosis. favorable prognostic factor
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