Exploitation of the 3-quinolinecarbonitrile template for SRC tyrosine kinase inhibitors.
作者： Diane Boschelli
DOI: 10.2174/156802608784911653
关键词:
摘要: In 2000, Wyeth reported that the 3-quinolinecarbonitrile ring system was a template for EGFR inhibitors. It soon became apparent group at C-4 of this core responsible kinase selectivity. A 4-(2,4-dichloro-5-methoxyanilino) substituent provided potent inhibitors Src, non-receptor tyrosine plays key role in cell signaling. One compound from series, SKI-606, bosutinib, is currently clinical trials treatment cancer.
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