Quinoline as a Privileged Scaffold in Cancer Drug Discovery

摘要: Quinoline (1-azanaphthalene) is a heterocyclic aromatic nitrogen compound characterized by double-ring structure that contains benzene ring fused to pyridine at two adjacent carbon atoms. compounds are widely used as "parental" synthesize molecules with medical benefits, especially anti-malarial and anti-microbial activities. Certain quinoline-based also show effective anticancer activity. This broad spectrum of biological biochemical activities has been further facilitated the synthetic versatility quinoline, which allows generation large number structurally diverse derivatives. includes numerous analogues derived from substitution quinoline system, derivatization structure. its analogs have recently examined for their modes function in inhibition tyrosine kinases, proteasome, tubulin polymerization DNA repair. In this review, we summarized our knowledge on respect activities, mechanisms action, structure-activity relationship (SAR), selective specific activity against various cancer drug targets. particular, focus review vitro vivo context development refinement.