Comparison of the efficacy of cell preparations from embryonic ventral mesencephalon of various prenatal age transplanted intrastriatally to rats with 6-OHDA-induced Parkinsonism.
作者： V. P. Chekhonin , S. V. Lebedev , T. B. Dmitrieva , D. V. Blinov , I. P. Lazarenko
关键词:
摘要: Cell preparations of ventral mesencephalon obtained from 8-, 14-, and 16-17-day rat embryos were stereotactically transplanted to homologous rats with 6-hydroxydopamine-induced hemiparkinsonism. Automated analysis apomorphine-induced motor asymmetry for 3 months after neurotransplantation revealed higher efficacy cell 8- lower 16-17-day-old embryos. These data correlated histomorphological findigs, in particular, the size grafts, glial reaction, number dopaminergic neurons grafts.
springer.com
sci-hub.se 参考文章(4)
Stephen B Dunnett, Anders Björklund, Neural transplantation : a practical approach Published in <b>1992</b> in Oxford by IRL press. ,(1992)
Isao Date, Takashi Ohmoto, Neural transplantation and trophic factors in Parkinson's disease : special reference to chromaffin cell grafting, NGF support from pretransected peripheral nerve, and encapsulated dopamine-secreting cell grafting Experimental Neurology. ,vol. 137, pp. 333- 344 ,(1996) , 10.1006/EXNR.1996.0034
K. Wictorin, P. Brundin, H. Sauer, O. Lindvall, A. Björklund, Long distance directed axonal growth from human dopaminergic mesencephalic neuroblasts implanted along the nigrostriatal pathway in 6‐hydroxydopamine lesioned adult rats The Journal of Comparative Neurology. ,vol. 323, pp. 475- 494 ,(1992) , 10.1002/CNE.903230403
Olle Lindvall, Restoration of Brain Function by Tissue Transplantation ,(1993)