Accelerated Atherosclerosis in Autoimmune Diseases

摘要: Atherosclerosis (AS) is a chronic inflammatory disease of arterial vessels, leading to and acute ischemic damage or hemorrhages in virtually any organ. Atherosclerotic plaque formation the result processes that mediate lymphocyte macrophage infiltration, lipid intra- inter-cellular deposition eventually smooth muscle cell migration/proliferation fibrosis. Immune responses against exogenous as well self-antigens cooperate triggering such processes. The atherogenic may be magnified accelerated patients with autoimmune rheumatic diseases (AIRDs) because underlying immune abnormalities, consequent systemic inflammation effects concomitant therapies. As matter fact, AS (AAS) responsible for increased mortality morbidity almost all AIRDs nowadays. Diagnostic strategies detect early atherosclerotic lesions apply preventive therapeutical approaches have been proposed order avoid complications related AAS AIRD.