ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor
作者： Jean-Paul Borg , Sylvie Marchetto , André Le Bivic , Vincent Ollendorff , Fanny Jaulin-Bastard
DOI: 10.1038/35017038
关键词:
摘要: The ERBB receptors have a crucial role in morphogenesis and oncogenesis. We identified new PDZ protein we named ERBIN (ERBB2 interacting protein) that acts as an adaptor for the receptor ERBB2/HER2 epithelia. contains 16 leucine-rich repeats (LRRs) its amino terminus (PSD-95/DLG/ZO-1) domain at carboxy terminus, belongs to family. directly specifically interacts with ERBB2/HER2. colocalize lateral membrane of human intestinal epithelial cells. ERBIN-binding site has critical restricting this basolateral cells, mutation leads mislocalization these suggest localization signalling
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sci-hub.se 参考文章(50)
Paul W Sternberg, José Alberola-Ila, Conspiracy theory: RAS and RAF do not act alone. Cell. ,vol. 95, pp. 447- 450 ,(1998) , 10.1016/S0092-8674(00)81612-8
A. S. Fanning, J. M. Anderson, PDZ Domains and the Formation of Protein Networks at the Plasma Membrane Current Topics in Microbiology and Immunology. ,vol. 228, pp. 209- 233 ,(1998) , 10.1007/978-3-642-80481-6_9
David Bilder, Norbert Perrimon, Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature. ,vol. 403, pp. 676- 680 ,(2000) , 10.1038/35001108
Leah N. Klapper, Mark H. Kirschbaum, Michael Seta, Yosef Yarden, Biochemical and Clinical Implications of the ErbB/HER Signaling Network of Growth Factor Receptors Advances in Cancer Research. ,vol. 77, pp. 25- 79 ,(1999) , 10.1016/S0065-230X(08)60784-8
Susan Tsunoda, Jimena Sierralta, Yumei Sun, Ruth Bodner, Emiko Suzuki, Ann Becker, Michael Socolich, Charles S. Zuker, A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade Nature. ,vol. 388, pp. 243- 249 ,(1997) , 10.1038/40805
Mingjie Zhang, Hidehito Tochio, Qiang Zhang, Pravat Mandal, Ming Li, Solution structure of the extended neuronal nitric oxide synthase PDZ domain complexed with an associated peptide Nature Structural & Molecular Biology. ,vol. 6, pp. 417- 421 ,(1999) , 10.1038/8216
Michelle L. Apperson, Il Soo Moon, Mary B. Kennedy, Characterization of Densin-180, a New Brain-Specific Synaptic Protein of the O-Sialoglycoprotein Family The Journal of Neuroscience. ,vol. 16, pp. 6839- 6852 ,(1996) , 10.1523/JNEUROSCI.16-21-06839.1996
Y Hata, S Butz, TC Sudhof, CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins The Journal of Neuroscience. ,vol. 16, pp. 2488- 2494 ,(1996) , 10.1523/JNEUROSCI.16-08-02488.1996
Tony Pawson, John D Scott, Signaling Through Scaffold, Anchoring, and Adaptor Proteins Science. ,vol. 278, pp. 2075- 2080 ,(1997) , 10.1126/SCIENCE.278.5346.2075
Jay E Brenman, Daniel S Chao, Stephen H Gee, Aaron W McGee, Sarah E Craven, Daniel R Santillano, Ziqiang Wu, Fred Huang, Houhui Xia, Matthew F Peters, Stanley C Froehner, David S Bredt, Interaction of Nitric Oxide Synthase with the Postsynaptic Density Protein PSD-95 and α1-Syntrophin Mediated by PDZ Domains Cell. ,vol. 84, pp. 757- 767 ,(1996) , 10.1016/S0092-8674(00)81053-3