Contribution of noradrenergic and adrenergic cell groups of the brainstem and agouti-related protein-synthesizing neurons of the arcuate nucleus to neuropeptide-Y innervation of corticotropin-releasing hormone neurons in hypothalamic paraventricular nucleus of the rat
作者： Tamás Füzesi , Gábor Wittmann , Zsolt Liposits , Ronald M. Lechan , Csaba Fekete
DOI: 10.1210/EN.2007-0732
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摘要: CRH-synthesizing neurons in the hypothalamic paraventricular nucleus (PVN) integrate neuronal and hormonal inputs serve as a final common pathway to regulate hypothalamic-pituitary-adrenal axis. One of regulators CRH is neuropeptide Y (NPY) contained axons that densely innervate neurons. The three main sources NPY innervation PVN are arcuate noradrenergic adrenergic brainstem. To elucidate origin NPY-immunoreactive (NPY-IR) hypophysiotropic neurons, quadruple-labeling immunocytochemistry for CRH, NPY, dopamine-β-hydroxylase, phenylethanolamine-N-methyltransferase was performed. Approximately 63% NPY-IR varicosities on surface were catecholaminergic (22% 41% adrenergic), 37% boutons noncatecholaminergic. By triple-labeling immunofluorescence detection agouti-related protein, marker pr...
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