Developmental regulation of Sertoli cell lactate production by hormones and the testicular paracrine factor, PModS
作者： Brian P. Mullaney , Marinella Rosselli , Michael K. Skinner
DOI: 10.1016/0303-7207(94)90052-3
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摘要: Abstract Testicular peritubular cells produce a paracrine factor termed PModS that mediates mesenchymal-epithelial interactions and modulates Sertoli cell functions essential for the process of spermatogenesis. lactate as preferred energy metabolite developing spermatogenic cells. The current study was designed to examine actions hormones on production at various stages pubertal development. were isolated from pre-pubertal (10 day), midpubertal (20 day) late (35 rat testes. Lactate accumulation in conditioned-medium cultured measured. Basal increased approximately fivefold during Therefore, increases differentiates ability regulatory agents such FSH or combination FSH, insulin, retinol testosterone (FIRT) stimulate decreased development differentiation increased. Purified stimulated preparations throughout had greater effect than stimulating production. with FIRT resulted an additive stimulation suggesting distinct mechanism action PModS. Observations support proposal locally produced these promote differentiated (i.e. production) required
sci-hub.se 参考文章(35)
Michael D. Griswold, Protein secretions of Sertoli cells International Review of Cytology-a Survey of Cell Biology. ,vol. 110, pp. 133- 156 ,(1988) , 10.1016/S0074-7696(08)61849-5
M K Skinner, P M Fetterolf, C T Anthony, Purification of a paracrine factor, P-Mod-S, produced by testicular peritubular cells that modulates Sertoli cell function. Journal of Biological Chemistry. ,vol. 263, pp. 2884- 2890 ,(1988) , 10.1016/S0021-9258(18)69151-3
Brian P. Mullaney, Michael K. Skinner, Growth factors as mediators of testicular cell-cell interactions. Baillière's clinical endocrinology and metabolism. ,vol. 5, pp. 771- 790 ,(1991) , 10.1016/S0950-351X(10)80014-X
N. H. P. M. Jutte, R. Jansen, J. A. Grootegoed, F. F. G. Rommerts, O. P. F. Clausen, H. J. van der Molen, Regulation of survival of rat pachytene spermatocytes by lactate supply from Sertoli cells Reproduction. ,vol. 65, pp. 431- 438 ,(1982) , 10.1530/JRF.0.0650431
Pierre S. Tung, Irving B. Fritz, Characterization of rat testicular peritubular myoid cells in culture: alpha-smooth muscle isoactin is a specific differentiation marker. Biology of Reproduction. ,vol. 42, pp. 351- 365 ,(1989) , 10.1095/BIOLREPROD42.2.351
Michael K. Skinner, Irving B. Fritz, Identification of a non-mitogenic paracrine factor involved in mesenchymal-epithelial cell interactions between testicular peritubular cells and Sertoli cells. Molecular and Cellular Endocrinology. ,vol. 44, pp. 85- 97 ,(1986) , 10.1016/0303-7207(86)90109-7
Marinella Rosselli, Michael K. Skinner, Developmental regulation of Sertoli cell aromatase activity and plasminogen activator production by hormones, retinoids and the testicular paracrine factor, PModS. Biology of Reproduction. ,vol. 46, pp. 586- 594 ,(1992) , 10.1095/BIOLREPROD46.4.586
J N Norton, M K Skinner, Regulation of Sertoli cell differentiation by the testicular paracrine factor PModS: potential role of immediate-early genes. Molecular Endocrinology. ,vol. 6, pp. 2018- 2026 ,(1992) , 10.1210/MEND.6.12.1491688
J.B. Yee, J.C. Hutson, Follicle-stimulating hormone-induced lactate secretion by cultured Sertoli cells does not require extracellular calcium. Life Sciences. ,vol. 44, pp. 1193- 1199 ,(1989) , 10.1016/0024-3205(89)90314-7
Ria B. Oonk, Ruud Jansen, J. Anton Grootegoed, Differential effects of follicle-stimulating hormone, insulin, and insulin-like growth factor I on hexose uptake and lactate production by rat Sertoli cells. Journal of Cellular Physiology. ,vol. 139, pp. 210- 218 ,(1989) , 10.1002/JCP.1041390128