Anti-osteoporosis Effect of Ganoderma (Lingzhi) by Inhibition of Osteoclastogenesis.
作者： Yajun Yang , Baoxue Yang
DOI: 10.1007/978-981-32-9421-9_11
关键词:
摘要: The anti-osteoporosis effect of Ganoderma lucidum (G. lucidum, Lingzhi) is closely associated with inhibition osteoclastogenesis in the charge osteoclasts. This article reviewed and its active components, including a kind triterpenoids, polysaccharide protein named Ling Zhi-8 (LZ-8). Triterpenoids are compounds as candidates for treatment osteoporosis. Among these, ganoderic acids currently considered most important potential their structure-activity relationship highlights essential group to hamper osteoclast differentiation. data confirmed that isolated from triterpenoids meroterpenoids could suppress bone resorption via RANKL/RANK pathway and/or downstream signaling transduction related ERK, JNK p38 MAPKs, contributing level c-Fos NFATc1, two key target genes osteoclastogenesis. However, comprehensive mechanism remains be elucidated future.
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