Photochemically induced thrombosis of the precentral cortex impairs operant variable-interval spatial delayed alternation performance by rats.

摘要: A variable-interval spatial delayed alternation memory task was used to quantify the behavioral effects of photochemically induced thrombic infarction precentral (frontal) cortex. Upon achieving criterion on task, rats received thrombicischemic lesions, predominantly limited medial cortex, by injection fluorescein dye Rose Bengal and illumination skull above target area. Beginning six days after surgery, were retested task. Compared Sham-operated controls (n = 5), with cortex lesions 5) demonstrated a retention interval-dependent accuracy deficit (impaired at longest interval only) slower reaction time (increased response latency). These significant only during first week postoperative testing. Rats also greater probability choice throughout three test weeks. The results suggest that photochemical thrombosis in produces functional, consequences which can be reliably objectively measured.