Sensory-motor deficit and recovery from thrombotic infarction of the vibrissal barrel-field cortex.

摘要: The present studies were undertaken to examine: (1) whether thrombotic infarction of the vibrissal cortical barrel-fields primary somatosensory cortex would produce behavioral consequences reflecting a sensory-motor deficit; and (2) there was any recovery function up two months after infarction. Specifically, in different learning tasks requiring integration, rats trained perform motor response consequent detection cues derived from either active exploration or passive deflection. Once training complete, unilateral, bilateral sham-infarction restricted region produced by non-invasive photochemical technique, which induces platelet-activated vascular occlusion combined with blood-brain barrier changes subsequent cell death. results demonstrated that, regardless sensory characteristics task, unilateral resulted reliable performance deficit, not sham-operated control animals. Thus, infarct disrupted ability integrate passively received actively acquired information previously associated response. However, unlike bilaterally infarcted animals, who displayed no level throughout postinfarction testing sessions, unilaterally animals exhibited gradual improvement beginning second third week recovering within 10-20% preinfarction levels between days 46-61. similarity temporal pattern groups, despite large differences demands tasks, may reflect several common underlying mechanisms recovery. Since similar deficits have been described human stroke, model incorporates many pathophysiological properties clinical situation be useful for future investigation therapeutic intervention.