The effect of sodium iodate on the blood-retinal and blood-brain barriers.
作者： Jens Taarnhöj , Albert Alm
DOI: 10.1007/BF00181783
关键词:
摘要: Both active transport through and permeability of the blood-retinal barrier (BRB) are affected by sodium iodate, while blood-brain (BBB) is more resistant. We studied effect iodate on facilitated diffusion two barriers. The retinal (RUI) brain (BUI) uptake indices were determined for d-glucose neutral amino acids in normal iodate-treated rats. integrity barriers was estimated RUI BUI l-glucose measuring tissue after an intravenous injection. found that 30 mg/kg had no or BBB, 20 significantly (P<0.02) reduced d-glucose, but not acids, BRB 1 h After 24 both caused a significant disruption (P<0.005 P<0.001, respectively). Thus, selectively affects carrier BBB. presence epithelial part BRB, pigment epithelium, may explain difference between
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