Effect of P-glycoprotein modulator, cyclosporin A, on the gastrointestinal excretion of irinotecan and its metabolite SN-38 in rats.
作者： Kazuhiko Arimori
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摘要: Purpose. The purpose of this work was to investigate the role hepatic and intestinal P-glycoprotein (P-gp) canalicular multispecific organic anion transporter /multidrug resistance-associated protein 2 (cMOAT/MRP2) on both biliary excretion exsorption irinotecan hydrochloride (CPT-11) its metabolite, SN-38, in lactone carboxylate forms. Cyclosporin A (CsA) used modulate P-gp cMOAT/MRP2.
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sci-hub.se 参考文章(25)
Kazuhiko Arimori, Masahiro Nakano, Drug exsorption from blood into the gastrointestinal tract. Pharmaceutical Research. ,vol. 15, pp. 371- 376 ,(1998) , 10.1023/A:1011959828103
Kazuhiko Arimori, Noriaki Kuroki, Ayumi Kumamoto, Naomi Tanoue, Masahiro Nakano, Eiji Kumazawa, Akiko Tohgo, Masahiko Kikuchi, Excretion into gastrointestinal tract of irinotecan lactone and carboxylate forms and their pharmacodynamics in rodents Pharmaceutical Research. ,vol. 18, pp. 814- 822 ,(2001) , 10.1023/A:1011040529881
Mark J. Ratain, Elora Gupta, Xiaolin Wang, Ahmad R. Safa, Pharmacokinetic Modulation of Irinotecan and Metabolites by Cyclosporin A Cancer Research. ,vol. 56, pp. 1309- 1314 ,(1996)
Hiroshi Kuga, Yasuhide Hirota, Yasuyoshi Kawato, Keiki Sato, Masashi Aonuma, Intracellular Roles of SN-38, a Metabolite of the Camptothecin Derivative CPT-11, in the Antitumor Effect of CPT-11 Cancer Research. ,vol. 51, pp. 4187- 4191 ,(1991)
Mary Vore, Liyue Huang, Tim Hoffman, Michael Gosland, Yong Liu, MDR1 substrates/modulators protect against beta-estradiol-17beta-D-glucuronide cholestasis in rat liver. Cancer Research. ,vol. 56, pp. 4992- 4997 ,(1996)
K Ueda, N Okamura, M Hirai, Y Tanigawara, T Saeki, N Kioka, T Komano, R Hori, Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone. Journal of Biological Chemistry. ,vol. 267, pp. 24248- 24252 ,(1992) , 10.1016/S0021-9258(18)35757-0
Ritchie Froehlich, Carol E. Green, Jack E. Dabbs, Valorie Weizer, Xiao-Yan Chu, Hiroshi Suzuki, Yukio Kato, Kaoru Ueda, Yuichi Sugiyama, Charles A. Tyson, Kayoko Niinuma, Biliary excretion mechanism of CPT-11 and its metabolites in humans: involvement of primary active transporters. Cancer Research. ,vol. 58, pp. 5137- 5143 ,(1998)
Robbert J. van Alphen, Alex Sparreboom, Kees Nooter, Ron H. J. Mathijssen, Walter J. Loos, Gerrit Stoter, Jaap Verweij, Clinical pharmacokinetics and metabolism of irinotecan (CPT-11) Clinical Cancer Research. ,vol. 7, pp. 2182- 2194 ,(2001)
Yuichi Sugiyama, Xiao-Yan Chu, Hiroshi Suzuki, Yukio Kato, Kaoru Ueda, Shin-Ichi Akiyama, Active Efflux of CPT-11 and Its Metabolites in Human KB-Derived Cell Lines Journal of Pharmacology and Experimental Therapeutics. ,vol. 288, pp. 735- 741 ,(1999)
Yuichi Sugiyama, Xiao-Yan Chu, Yukio Kato, Possible involvement of P-glycoprotein in biliary excretion of CPT-11 in rats. Drug Metabolism and Disposition. ,vol. 27, pp. 440- 441 ,(1999)