Clinical pharmacokinetics and metabolism of irinotecan (CPT-11)
作者： Robbert J. van Alphen , Alex Sparreboom , Kees Nooter , Ron H. J. Mathijssen , Walter J. Loos
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摘要: CPT-11 belongs to the class of topoisomerase I inhibitors, and it acts as a prodrug of SN-38, which is approximately 100–1000-fold more cytotoxic than the parent drug. CPT-11 has …
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