Effects of systemic chemotherapy on the liver.

摘要: The liver is the largest parenchymatous organ of body and central for intermediate metabolism. Its close contact to portal blood streaming back from gut systemic circulation a prerequisite various processes ongoing on cellular level. spatial relationship hepatocytes with different structures liver, such as fenestrated sinusoidal endothelial cells, Kupffer bile canaliculi important organization performance metabolism nutrients (proteins, glucose fatty acids), clearance toxic or infectious agents, metabolic detoxification excretion waste products. administration chemotherapy challenge tight regulation balance these processes. As most drugs tend be lipophilic, they are readily taken up by liver. Under chemotherapy, 85% patients develop steatosis. Steatohepatitis more serious event, especially if accompanied an increase in bilirubin levels. Modern understanding efficacy, safety tolerability combination has increasingly include individual context patient, age, gender, nutritional status, underlying diseases, genetic predisposition, well cross-reactivity drugs. This review tries capture effects focus chemotherapeutical compounds used treatment gastrointestinal cancers.