BIOCHEMICAL INDICATORS OF HEPATOTOXICITY IN BLOOD SERUM OF RATS UNDER THE EFFECT OF NOVEL 4-THIAZOLIDINONE DERIVATIVES AND DOXORUBICIN AND THEIR COMPLEXES WITH POLYETHYLENEGLYCOL-CONTAINING NANOSCALE POLYMERIC CARRIER.
作者： Lesyk Rb , Zimenkovsky Bs , Havrylyuk Dy , Kobylinska Li , Zaichenko Os
DOI:
关键词:
摘要: The aim of this study was to compare the effect new synthetic 4-tiazolidinone derivatives (compounds 3882, 3288 and 3833) doxorubicin (positive control) in free form their complexes with polyethyleneglycol-containing nanoscale polymeric carrier on biochemical indicators hepatotoxicity blood serum rats. activity enzymes considered as markers hepatotoxicity, well as. concentration total protein, urea creatinine were measured It found that after injection investigated compounds activities ofalanine aminotransferase, alkaline phosphatase α-amylase increased comparison control. Doxorubicin accompanied by 4-fold increase γ-glutamyltransferase, ofcompound 3833 led 2.5-fold elevation ofthe enzyme. Complexation ofthese antineoplastic a nanocarrier lowered substantially if compared these infreeform. most evident decrease for α-amylase, γ-glutamyltransferase lactate dehydrogenase activities. normalization concentrations rats treated studied comparing introduction infreeform also detected. Thus, immobilization novel anticancer drugs possessing high general toxicity organism mitigates toxic effect, which is specific hepatodestructive effects drugs.
ukrbiochemjournal.org 参考文章(9)
Giuliano Ramadori, Silke Cameron, Effects of systemic chemotherapy on the liver. Annals of Hepatology. ,vol. 9, pp. 133- 143 ,(2010) , 10.1016/S1665-2681(19)31651-5
Kuldip Singh Sodhi, Harnam Kaur, Shikhaa Mahajan, Neeru Bhaskar, Jasbir Singh, Mukund Joshi, Rajesh Pandey, Subhash Goyal, Suvarna Prasad, CANCER CHEMOTHERAPY AND HEPATOTOXICITY: AN UPDATE Indo American Journal of Pharmaceutical Research. ,vol. 4, pp. 2976- 2984 ,(2014)
Hyman J. Zimmerman, Hepatotoxicity: The Adverse Effects of Drugs and Other Chemicals on the Liver ,(1978)
Dmytro Havrylyuk, Borys Zimenkovsky, Olexandr Vasylenko, Andrzej Gzella, Roman Lesyk, Synthesis of new 4-thiazolidinone-, pyrazoline-, and isatin-based conjugates with promising antitumor activity. Journal of Medicinal Chemistry. ,vol. 55, pp. 8630- 8641 ,(2012) , 10.1021/JM300789G
Shelton D Caruthers, Samuel A Wickline, Gregory M Lanza, Nanotechnological applications in medicine Current Opinion in Biotechnology. ,vol. 18, pp. 26- 30 ,(2007) , 10.1016/J.COPBIO.2007.01.006
Dhruba J Bharali, Marianne Khalil, Mujgan Gurbuz, Tessa M Simone, Shaker A Mousa, None, Nanoparticles and cancer therapy: a concise review with emphasis on dendrimers. International Journal of Nanomedicine. ,vol. 4, pp. 1- 7 ,(2009) , 10.2147/IJN.S4241
Y. Senkiv, A. Riabtseva, P. Heffeter, N. Boiko, C. R. Kowol, U. Jungwith, Y. Shlyakhtina, S. G. Garasevych, N. Mitina, W. Berger, A. Zaichenko, R. Stoika, Enhanced anticancer activity and circumvention of resistance mechanisms by novel polymeric/ phospholipidic nanocarriers of doxorubicin. Journal of Biomedical Nanotechnology. ,vol. 10, pp. 1369- 1381 ,(2014) , 10.1166/JBN.2014.1864
Dmytro Havrylyuk, Borys Zimenkovsky, Olexandr Vasylenko, Roman Lesyk, Synthesis and Anticancer and Antiviral Activities of New 2‐Pyrazoline‐Substituted 4‐Thiazolidinones Journal of Heterocyclic Chemistry. ,vol. 50, ,(2013) , 10.1002/JHET.1056
Anna Riabtseva, , Nataliya Mitina, Nataliya Boiko, Sergiy Garasevich, Igor Yanchuk, Rostyslav Stoika, Oleksandr Slobodyanyuk, Alexander Zaichenko, , , , , , , , Structural and Colloidal-Chemical Characteristics of Nanosized Drug Delivery Systems Based on Pegylated Comb-Like Carriers Chemistry and Chemical Technology. ,vol. 6, pp. 291- 295 ,(2012) , 10.23939/CHCHT06.03.291