CANCER CHEMOTHERAPY AND HEPATOTOXICITY: AN UPDATE

摘要: Article history Cytotoxic chemotherapy prolongs survival of patients with advanced and metastatic tumors. Since the liver has a rich blood supply plays an active role in metabolism medications, it is not surprising that there can be hepatic toxicity related to chemotherapy. In addition, radioembolization may affect parenchyma normal cirrhotic livers. The administration challenge for tight regulation balance these processes. As most drugs tend lipophilic, they are readily taken up by liver. Under chemotherapy, 85% develop steatosis. Steatohepatitis more serious event, especially if accompanied increase bilirubin levels. Modern understanding efficacy, safety tolerability combination increasingly include individual context patient, such as age, gender, nutritional status, underlying diseases, genetic predisposition, well cross-reactivity different drugs. This review tries capture various effects on highlight pharmacogenomics insults.