Liver Cancer (Hepatocellular Carcinoma)

摘要: Liver cancer is global health problem, claiming hundreds of thousands deaths every year. Despite significant efforts by doctors, scientists and the pharmaceutical industry, treatment options for hepatocellular carcinoma (HCC) remain poor, with 5-year survival rates approximately 15%. The paucity viable clinical treatments available HCC patients has prompted many to look outside boundaries traditional cytotoxic chemotherapeutic consider targeting epigenetic make up malignant hepatocytes. Most commonly, this approach aimed at altering activity histone deacetylases, a family 18 proteins that play an important role in gene regulation, along DNA methylation. central mechanisms was originally proposed result from normalization aberrant regulation within tumors but now understood be far more wide reaching, effects demonstrated against variety cellular processes, including metabolism, migration, proliferation, endoplasmic reticulum stress. advent powerful tools form agents have potential alter course been highlighted. Nonetheless, rough diamond needs further refinement clarity truly access their benefit. Increases cases hand limited persistently low glimmer hope fight liver cancer.