Predicting etoposide toxicity: relationship to organ function and protein binding.
作者： S P Joel , R Shah , P I Clark , M L Slevin
DOI: 10.1200/JCO.1996.14.1.257
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摘要: PURPOSETo investigate the effect of organ function on total and free etoposide pharmacokinetics hematologic toxicity.PATIENTS AND METHODSSeventy-two patients who received single-agent intravenous (i.v.) over 5 or 8 days (total dose, 500 mg/m2) were studied. Pharmacokinetic parameters derived after analysis plasma by high-performance liquid chromatography (HPLC) with ultraviolet (UV) detection, protein binding ultrafiltration an etoposide-spiked, pretreatment serum sample, followed HPLC analysis. Free area under concentration-time curve (AUC) was from AUC binding.RESULTSPatients renal impairment (serum creatinine level > 130 mumol/L) had a lower clearance (13.6 v 18.5 mL/min/m2; P = .016), resulting in increased total-drug free-drug 615 452 micrograms/mL.hr; .016; 26.0 17.6 .026) hematolo...
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