Antagonistic effects of different selenium sources on growth inhibition, oxidative damage, and apoptosis induced by fluorine in broilers
作者： Y.X. Wang , X Xiao , X.A. Zhan
DOI: 10.3382/PS/PEY192
关键词:
摘要: Fluorosis can induce oxidative stress through leading to reactive oxygen species (ROS) generation. Selenium (Se) eliminate ROS by direct and indirect manners. In this study, therefore, we investigated the possible protective effects of sodium selenite (SS) selenomethionine (Se-Met) on fluorine (F)-induced in broilers. A total 720 1-day-old Lingnan Yellow broilers were allotted 4 groups (6 replicates 30 birds each group) fed with basal diet (control group), 800 mg/kg F (high F+0.15 mg Se/kg as SS (SS or Se-Met (Se-Met respectively. The experiment lasted 50 d. High group significantly decreased (P < 0.05) average daily gain (ADG) feed efficiency (FE) comparison control group. contents ROS, malondialdehyde, 8-hydroxydeoxyguanosine, protein carbonyl, cysteinyl aspartate specific proteinases 3 serum, liver, kidney higher high than those Compared group, activities glutathione peroxidase (GSH-Px) cytoplasmic thioredoxin reductase (TrxR1) well selenoprotein P (SelP), (TP), B-cell lymphoma-2 serum tissues observed Moreover, pathological lesions liver more However, supplementation could improve ADG FE, increase SelP TP concentrations, elevate GSH-Px TrxR1 activities, minimize changes apoptosis parameters ultrastructure kidney, whereas better SS. results indicated that excess result growth inhibition inducing subsequently caused damage biological macromolecules soft apoptosis, dietary antagonize induced retardation inhibiting a mechanism regulation impact was Se-Met.
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