The effect of alterations in myc gene expression on B cell development in the bursa of fabricius
作者： Craig B. Thompson , Eric H. Humphries , Louise M. Carlson , Chen-Lo H. Chen , Paul E. Neiman
DOI: 10.1016/0092-8674(87)90633-7
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摘要: Abstract Infection of 18-day embryonic bursal lymphocytes with a v- myc -containing retrovirus leads directly to polyclonal proliferation surface immunoglobulinpositive (slg + cells in the bursa Fabricius detected four weeks after hatching. These -expressing repopulate follicles chemically ablated bursae more efficiently than total normal cells. In contrast, comparable lose ability by weeks. Bursal expressing either retroviral or c- gene deregulated adjacent integration retain diversify their immunoglobulin light chain genes. results suggest that deregulation expression during avian B cell development induces outgrowth population cardinal phenotypic characteristics stem
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