Light chain gene conversion continues at high rate in an ALV-induced cell line.

作者: J.M. Buerstedde , C.A. Reynaud , E.H. Humphries , W. Olson , D.L. Ewert

DOI: 10.1002/J.1460-2075.1990.TB08190.X

关键词:

摘要: We have analyzed immunoglobulin light chain sequences from avian leukosis virus (ALV) induced bursal and metastatic tumors cell lines derived these tumors. Sequence data presented demonstrate that ALV-induced one line (DT40) therefrom continue to diversify their genes outside of the environment. Diversification within tumor cells seems occur by gene conversion events comparable with those observed in B cells. analysis spontaneously arising surface negative subclones DT40 revealed frameshifts rearranged which most likely resulted non-functional recombination events. Superimposed can repair leading re-expression immunoglobulin.

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