Embryonic Atrazine Exposure Elicits Alterations in Genes Associated with Neuroendocrine Function in Adult Male Zebrafish

摘要: The developmental origins of health and disease (DOHaD) hypothesis states that exposure to environmental stressors early in life can elicit genome epigenome changes resulting an increased susceptibility a state during adulthood. Atrazine, common agricultural herbicide used throughout the Midwestern United States, frequently contaminates potable water supplies is suspected endocrine disrupting chemical. In our previous studies, zebrafish was exposed 0, 0.3, 3, or 30 parts per billion (μg/l) atrazine through embryogenesis, rinsed, allowed mature A decrease spawning observed with morphological alterations offspring. addition, adult females displayed increase ovarian progesterone follicular atresia, levels serotonin metabolite turnover brain tissue, transcriptome tissue supporting neuroendocrine alterations. As reproductive dysfunction also influenced by males, this study assessed testes histology, hormone levels, transcriptomic profiles males. embryonic resulted no body weight, gonadosomatic index, 11-ketotestosterone testosterone. To further investigate potential alterations, male completed. This analysis demonstrated genes associated abnormal cell neuronal growth morphology; molecular transport, quantity, production steroid hormones; neurotransmission emphasis on hypothalamus-pituitary-adrenal hypothalamus-pituitary-thyroid axes. Overall, data indicate future studies should focus additional endpoints determine functional impairments.