Inhibition of Human Melanoma Growth and Metastasis in Vivo by Anti-CD44 Monoclonal Antibody

摘要: Abstract CD44 is a M r 90,000 surface glycoprotein believed to be involved in cell adhesion and migration. We investigated the role of tumor growth metastasis using human melanoma lines SMMU-1 SMMU-2. Both SMMU-2 form tumors s.c. tissues when injected SCID mice but only metastasizes. Approximately one-half receiving injections develop metastatic tumors. not expresses high levels hematopoietic binds fluorescence-conjugated hyaluronic acid vitro . GKW.A3 monoclonal antibody specific for that can completely inhibit binding cells Moreover, vivo injection inhibited potential cells. Administration i.v. 1 week after did local development formation prolonged animal survival. Therefore, interactions between on its ligands may necessary metastasis.